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Carnitine and L-carnitine, TRADE NAMESCarnitine and L-carnitine are available generically from numerous manufacturers. Branded products include Carnitor (Sigma-Tau), Carnitine-300 (Key Company), Carni Fuel (Twinlab), Mega L-Carnitine (Twinlab) and Maximal Burner Carnitine (Bricker Labs), Proxeed (Sigma-Tau).
L-carnitine, an amino acid derivative, is found in nearly all cells of the body. L-carnitine transports long-chain fatty acids across the inner mitochondrial membranes in the mitochondria, where they are processed by beta-oxidation to produce biological energy in the form of adenosine triphosphate or ATP.
L-carnitine is known chemically as (R)-3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner salt; beta-hydroxy-gamma-N,N,N-trimethylaminobutyrate; gamma-amino-beta-hydroxybutyric acid trimethylbetaine; (3-carboxy-2-hydroxypropyl) trimethylammonium hydroxide, inner salt; gamma-trimethyl-beta-hydroxybutyrobetaine, and 3-hydroxy-4-(trimethylammonio) butanoate. L-carnitine is also known as levocarnitine and was formerly called vitamin BT. L-carnitine is a quarternary amine and belongs to the same chemical family as choline and is soluble in water.
L-carnitine occurs naturally in animal products. Generally, only very small amounts of it are found in plants, with few exceptions, such as avocado and some fermented soy products, e.g. tempeh. L-carnitine is a chiral molecule. Its stereoisomer D-carnitine does not have the biological activity of L-carnitine and may even antagonize L-carnitine in its biological roles.
L-carnitine is synthesized in the human body, chiefly in the liver and kidneys, from the essential amino acids L-lysine and L-methionine. Niacin, vitamins B6 and C, and iron are involved in its biosynthesis. L-carnitine is described as a conditionally essential nutrient. This refers to certain conditions where exogenous L-carnitine may be required, such as in long-term parenteral nutrition, those on valproic acid therapy and possibly for the elderly.
L-carnitine is available in a few forms. Oral L-carnitine is available as a nutritional supplement and as a prescribed orphan drug treatment for primary and secondary L-carnitine deficiencies. Intravenous L-carnitine (levocarnitine) is available as a prescription orphan drug for the treatment of primary and secondary L-carnitine deficiencies. Acetyl-L-carnitine, another delivery form of both L-carnitine and acetyl groups, is available as a nutritional supplement. Another delivery form of L-carnitine, proprionyl-L-carnitine, is available in Europe but not at present in the U.S.
Supplemental L-carnitine may have cardioprotective activity in addition to beneficially affecting cardiac function. It may have a triglyceride-lowering effect in some as well as help to elevate HDL-cholesterol levels. L-carnitine may also have antioxidant properties.
Acetyl-L-carnitine may have neuroprotective activity. It may also aid in the treatment of age-related cholinergic deficits, such as those found in dementia disorder, including Alzheimer's disease (see Acetyl-L-carnitine).
The strongest evidence for the use of supplemental L-carnitine may be in the management of cardiac ischemia and peripheral arterial disease. It may also more generally be indicated for cardioprotection. It lowers triglyceride levels and increases levels of HDL-cholesterol in some. It is used with some benefit in those with primary and secondary carnitine deficiency syndromes. There is less evidence to support arguments that carnitine is indicated in liver, kidney and immune disorders or in diabetes and Alzheimer's disease. There is little evidence that supplemental L-carnitine boosts energy, increases athletic performance or inhibits obesity. There is no support for the claim that healthy vegetarians require L-carnitine supplementation.
Brain Health and Acetyl-L-Carnitine Acetyl-L-carnitine more readily crosses the blood-brain barrier than do other forms of L-carnitine, and in the human brain, the acetylation of L-carnitine is a normal event. This is one explanation sometimes given for the greater activity found with acetyl-L-carnitine than other forms of L-carnitine in the brain.
Acetyl-L-carnitine promotes healthy neural levels of acetylcholine, a major neurotransmitter that helps memory and proper brain function. Researchers have discovered that acetyl-L-carnitine acts as an antioxidant within the brain, that it promotes stabilization of cell membranes, enhances energy production within brain cells, and supports the functions of acetylcholine.
Acetyl L-Carnitine Research Cellular energy production itself produces free radicals that can harm cell structures, including the mitochondria, if the body's natural antioxidant capacity is low. Acetyl l-carnitine and lipoic acid are both naturally present antioxidants in the body that have been shown to support mitochondrial function and help reduce free radical damage.
Acetyl l-carnitine enhances energy production by promoting the transport of fatty acids into the energy-producing units in the cells. In two animal studies from the University of California at Berkeley acetyl l-carnitine significantly benefited mitochondrial health and prmoted increased cellular respiration and membrane health.
Acetyl-L-carnitine may offer unprecedented hope for people suffering from Alzheimer's disease or the aftereffects of a stroke. The human brain is uniquely powerful and complex, but it is sometimes difficult for it to fully recover from damage. People who have been affected by stroke, traumatic brain damage or age-associated dementia know this all too well. Fortunately, research studies suggest that the vitamin-like nutrient L-carnitine may be able to slow down, or even reverse, brain deterioration. Plus, it may give people the ability to think clearer and remember things
Liquid L-CARNITINE :Just one tablespoon of liquid L-Carnitine will fire up your body’s "fat burning furnace" to burn fat and increase metabolism for weight loss. Get more from each workout as liquid carnitine helps your body to burn more fat as fuel and increase metabolism. Unlock the energy stored in your fat to lose weight and realize YOUR full potential. See and feel weight loss immediately when using our liquid L Carnitine!
LIQUID CARNITINE :
Boost of Energy
Endurance Athletes & Bodybuilders
Pre-Work Out Formula
LIQUID CARNITINE :
USE YOUR FAT FOR ENERGY
Work Out Enhancer
Ideal for GYM MEMBERS, BODY BUILDERS, MODELS
HIGH ABSORBANCE LIQUID
ALL NATURAL SUPPLEMENT AIDS in FAT LOSSThe amino acid that is responsible for the transport of fats in the body is included, without L-Carnitine you will not burn fats as energy. Research has shown that accelerated levels of energy from fats are attainable when L-Carnitine is available to the muscle during exercise. Burn fat effeciently. Use fat for muscle energy.
If your diet is low in fats and red meat, it is possible that you have little or no L-Carnitine from natural sources, and that you may need to supplement L-Carnitine.
RESEARCH & STUDIES:The amino acid that is responsible for the transport of fats in the body is included. Without L-Carnitine you will not burn fats as energy. Research has shown that accelerated levels of energy from fats are attainable when L-Carnitine is available to the muscle during exercise.
Not isolated until 1957, L-Carnitine has been revealed to play an important role in the regulation of fat burning. Carnitine determines how much fat can flow into the mitochondria of body cells to serve as fuel for energy production.
There are numerous studies covering the positive benefits and importance of amino acids to proper body functioning and optimized health.
DOSES & DIRECTIONS:Adults should take 1-3 teaspoons per day or as directed by physician.
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*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease
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