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What is Glucosamine Sulfate?
Glucosamine Sulfate (also known as Glucosamine Sulphate) is the form that has been tested in dozens of clinical trials. It is very similar to glucosamine HCL (hydrochloride) in effectiveness, because the sulfate is simply a carrier molecule for the actual glucosamine.
Another popular form of glucosamine is known as glucosamine HCL, or hydrochloride. Some studies have shown the HCL to be more effective and some have shown the sulfate to be more effective, so it would be prudent to either try both individually (probably not the most cost effective option) and see which one works better for you, or ideally simply find a product that contains both HCL and Sulfate.
Where Does Glucosamine Sulfate Come From?All of the glucosamine forms originated from shellfish, and has been shown since the first clinical studies in 1980 to be effective at easing discomfort associated with arthritis - at least - if not more effectively than common non-steroidal anti-inflammatory drugs (NSAIDS) such as Ibuprofen or Aspirin. Glucosamine sulfate(and HCL) also has very few side effects in comparison to NSAIDS, which can erode your digestive tract and cause internal bleeding, liver failure or death when taken over time or in people over the age of about 45 when your body being to not be able to heal quite as effectively. “Anti-inflammatory drugs (prescription and over-the-counter, which include Advil®, Motrin®, Aleve®, Ordus®, Aspirin, and over 20 others) alone cause over 16,500 deaths and over 103,000 hospitalizations per year in the US”, according to a review article published in the New England Journal of Medicine.
For long term care, simply masking your pain with NSAIDS is not the solution, particularly in light of the facts of how toxic they can potentially be. Many of the newer COX-2 medications such as Vioxx® or are not much better either. They are “selective” but only slightly more so than the NSAIDS, and their toxicity and side effect lists can be extensive. The main concern about COX 2 drugs is their potential for blood clotting - which can mean strokes, heart attacks or worse.
Types of Glucosamine to Avoid
Glucosamine sulfate alone is perfectly ok, but you should avoid glucosamine sulfate * NaCL (or KCl) (or if the ingredients list says potassium or salt after the sulfate). Some companies are very tricky about this - unless it just says glucosamine sulfate or HCL, you likely are getting an inferior product. It is easy for people to see the glucosamine sulfate and simply ignore the KCl on the end. We are not all molecular scientists after all. The NaCl and KCl ("the salts") refer to even more (unneeded but cheaper) carrier molecules that can be up to 30% of the product's weight. Some carrier molecule is needed (such as sulfate or HCL alone) because raw glucosamine is unstable by itself - it needs to be bound to the sulfate or HCL carrier in order to be stored for any period of time. So if you have one of the KCl or NaCl forms of the sulfate when you think you are buying a quality product, you are actually getting 30% of your dose as ordinary table salt. Be advised to watch out for products with those markings. The less active amounts of glucosamine you get, the slower your relief will be. At some point it will likely be so low that you will get no benefit at all. NAG (N-Acetylglucosamine or N-Acetyl-D-Glucosamine), is another rarer form of glucosamine but should generally be avoided due to its relative ineffectiveness and expense.
What Kind of Glucosamine Should I Buy?
There are so many different forms and types and brands of glucosamine out there and the quality varies widely. It is advised that one seek out a reputable manufacturer (one that offers a full, no questions asked, money back guarantee) and follow the old adage that you get what you pay for. It can also be helpful to look at the label before you buy or get recommendations from other people you know that use glucosamine. A good liquid brand should run you about a dollar a day or slightly less and include glucosamine sulfate or HCL or both and other "synergistic" (effective in combination) ingredients as well. Again, glucosamine in tablet form is not recommended due to low absorption issues. Some of the better formulas contain will also contain chondroitin and MSM.
BACKGROUND: Conventional symptomatic treatments for osteoarthritis do not favorably affect disease progression. The aim of this randomized, placebo-controlled trial was to determine whether long-term (3-year) treatment with glucosamine sulfate can modify the progression of joint structure and symptom changes in knee osteoarthritis, as previously suggested.
METHODS: Two hundred two patients with knee osteoarthritis (using American College of Rheumatology criteria) were randomized to receive oral glucosamine sulfate, 1500 mg once a day, or placebo. Changes in radiographic minimum joint space width were measured in the medial compartment of the tibiofemoral joint, and symptoms were assessed using the algo-functional indexes of Lequesne and WOMAC (Western Ontario and McMaster Universities).
RESULTS: Osteoarthritis was of mild to moderate severity at enrollment, with average joint space widths of slightly less than 4 mm and a Lequesne index score of less than 9 points. Progressive joint space narrowing with placebo use was -0.19 mm (95% confidence interval, -0.29 to -0.09 mm) after 3 years. Conversely, there was no average change with glucosamine sulfate use (0.04 mm; 95% confidence interval, -0.06 to 0.14 mm), with a significant difference between groups (P =.001). Fewer patients treated with glucosamine sulfate experienced predefined severe narrowings (>0.5 mm): 5% vs 14% (P =.05). Symptoms improved modestly with placebo use but as much as 20% to 25% with glucosamine sulfate use, with significant final differences on the Lequesne index and the WOMAC total index and pain, function, and stiffness subscales. Safety was good and without differences between groups.
CONCLUSION: Long-term treatment with glucosamine sulfate retarded the progression of knee osteoarthritis, possibly determining disease modification.
Glucosamine is a substance that occurs naturally in the human body. It provides strength, flexibility, and elasticity to cartilage and connective tissue by stimulating the production of glycosaminoglycans, molecules that hold joint tissue together. Glucosamine also decreases inflammation that can lead to the joint destruction of arthritis.
With the potential to repair damaged joints and slow the progression of arthritis, glucosamine has become an immensely popular dietary supplement around the world. In 1999, glucosamine was the top-selling dietary supplement in the United States, with annual sales of US $288 million.
However, a few clinical reports have suggested side effects that even health practitioners were initially unaware of. One woman reported that her diabetes symptoms worsened after taking glucosamine.
Glucosamine is ten times as potent as regular glucose in causing insulin resistance in animals. Glucosamine can increase fasting blood sugar levels and worsen glucose tolerance.
These side effects occur because glucosamine activates a metabolic pathway in the body that leads to the deterioration of insulin-producing cells in the pancreas and causes insulin resistance, two factors associated with diabetes.
Researchers at Johns Hopkins recently found that activation of this pathway, called the hexosamine pathway, causes proteins to be coated in sugar, preventing them from passing along insulin's message to regulate blood glucose.
Many studies have been conducted around the world on glucosamine, yet these side effects have not been noted. It may be that only certain people will react. Further study is needed on the safety of the oral supplement form. Until then, people taking glucosamine sulfate should consult a natural health practitioner.
Glucosamine Sulfate Advanced Arthritis FormulaSuffering from muscle and joint pain from over-training, over-exertion or arthritis? Now get natural pain relief from arthritis pain or joint pain and stop masking pain with aspirin! Glucosamine Sulfate actually heals body tissues and offers joint repair & cartilage repair to keep you active and feeling great. Give your body what it needs to repair itself and have natural pain relief. You’ll be amazed at its effectiveness!
GLUCOSAMINE SULFATE ARTHRITIS FORMULA :
Body Builders & Athletes
GLUCOSAMINE SULFATE ARTHRITIS FORMULA :
Lessens MUSCLE & JOINT PAIN
REBUILDS & REPAIRS TISSUES
Ideal for ATHLETES & OLDER ADULTS
ALL NATURAL SUPPLEMENTGLUCOSAMINE SULFATE is an amino sugar normally formed in humans from glucose. It is the starting point for the synthesis of many important macromolecules including: glycoproteins, glycolipids, and glycos- aminoglycans (mucopolysaccharides). These macromolecules make up many of the body's tissues including: basement membranes, mucous membranes in the digestive and respiratory tracts, and synovial fluid in the joints. Arthritis Medication Alternative
Help Ease These Symptoms:
Joint Use Pain
Loss of Joint Function
Joint "cracking" upon movement
A deficiency of glucosamine can reduce the rate of production of these important macromolecules thereby leading to specific tissue weakness. In certain cases of trauma to the tissues, the amount of glucosamine normally synthesized by the body is insufficient. The tissues containing these glucosamine macromolecules include tendons and ligaments, cartilage, synovial fluid, mucus membranes, several structures in the eye, blood vessels, and heart valves.
RESEARCH & STUDIES:There are numerous studies covering the positive benfits and importance of amino acids to proper body functioning and optimized health.
Kaufman, W. The use of vitamin therapy to reverse certain concomitants fo aging. J.Am.Geriatr Soc 1955;11-927-936
Machaty, I, Ouaknina, L. Tocopherol in osteoarthritis; a controlled piolot study. J. Am Geriatr Soc 1976; 26:323-330
O'Ambrosia, E. et al. Glucosmine sulfate; a controlled clinical investigation in arthritis. Pharmatherapeutica 1991; 2:504-508
Vaz, A.L. Double-blind clinical evaluation of the relative efficacy of ibuprofen and glucosamine sulfate in the management of osteoarthritis of the knee in out-patients. Curr. Med Res. Opin., 8:145-9, 1982.
DOSES & DIRECTIONS:Directions:
Adults, One capsule three times daily, or as directed by a Health Care Professional.
Keep tightly closed in a cool dry place.
INGREDIENTS:Excipients: Rice Flour Contains no artificial preservatives, coloring, flavors, salt soy, sugar, starch, wheat or yeast
Each capsule contains: Glucosamine Sulfate. . . . . . . 750 mgs.
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*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure or prevent any disease
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