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Calcium Pyruvate: Pyruvic Acid, Calcium Salt (C3H3O3Ca )

Pyruvate supplies the body with pyruvic acid, a natural compound that plays important roles in the manufacture and use of energy. Pyruvate supplements have become popular with bodybuilders and other athletes, based on claims that pyruvate can reduce body fat and enhance the ability to use energy efficiently. However, at the present time, there is only preliminary evidence that it really works. Sources: Pyruvate is not an essential nutrient, since your body makes all it needs. But it can be found in food, with an average diet supplying anywhere from 100 mg to 2 g daily. Apples are the best source: a single apple contains about 450 mg of pyruvate. Beer and red wine contain about 75 mg per serving. Therapeutic dosages are usually much higher than what you can get from food: You'd have to eat almost 70 apples a day to get the proper amount! To use pyruvate for therapeutic purposes, you must take a supplement. Although most products on the market contain only (or almost only) pyruvate, some also contain a related compound, dihydroxyacetone, which the body converts to pyruvate. The combination of the two products is known as DHAP. Therapeutic Dosages A typical therapeutic dosage of pyruvate is 30 g daily, although 6 to 44 g daily have been used in studies. Dihydroxyacetone dosages in studies of DHAP (pyruvate plus dihydroxyacetone) have ranged from 12 to 75 g daily. Therapeutic Uses Evidence from several small placebo-controlled studies suggests that pyruvate may enhance weight loss. Pyruvate is also marketed as a sports performance supplement, but the supporting evidence for this use is weak and contradictory at best. What Is the Scientific Evidence for Pyruvate? Weight Reduction Several small studies enrolling a total of about 150 individuals have found evidence that pyruvate or DHAP can aid weight loss and/or improve body composition (the proportion of fat to muscle tissue). For example, in a 6-week double-blind, placebo-controlled trial, 51 individuals were given either pyruvate (6 g daily), placebo, or no treatment. All participated in an exercise program. In the treated group, significant decreases in fat mass (2.1 kilograms) and percentage body fat (2.6%) were seen, along with a significant increase in muscle mass (1.5 kilograms). No significant changes were seen in the placebo or non-treatment groups.

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Another placebo-controlled study used a much higher dose of pyruvate, 22 to 44 g daily depending on total calorie intake.In this trial, 34 overweight individuals were put on a mildly weight-reducing diet for 4 weeks. Subsequently, half were given a liquid dietary supplement containing pyruvate. Over the course of 6 weeks, individuals in the pyruvate group lost a small amount of weight (about 1-1/2 pounds) while those in the placebo group did not lose weight. Most of the weight loss came from fat. While all these studies show some benefits, we need larger studies (100 participants or more) to establish the potential benefits of pyruvate for weight loss. Safety Issues Both pyruvate and dihydroxyacetone appear to be quite safe, aside from mild side effects such as occasional stomach upset and diarrhea. Very weak evidence (too weak to get very concerned about) hints that pyruvate supplements might adversely affect cholesterol profile by negating the positive effects of exercise on HDL. Maximum safe dosages for children, women who are pregnant or nursing, or those with liver or kidney disease have not been established. 100% Natural Calcium Pyruvate Capsules: Suppress your appetite to lose weight and to speed up weight loss! Burn fat and inhibit regain for weight loss that lasts and to increase endurance during workouts while preserving valuable muscle! 100% natural Calcium Pyruvate capsules is one of the most exciting weight loss supplements available because IT WORKS to help you lose weight!! CALCIUM PYRUVATE WEIGHT LOSS FORMULA: Dieters Endurance Athletes & Bodybuilders Office Workers Pre-Work Out Formula Click for CALCIUM PYRUVATE WEIGHT LOSS FORMULA: USE AS AN APPETITE SUPPRESSENT INCREASE YOUR ENDURANCE Ideal for GYM MEMBERS, BODY BUILDERS, MODELS ASSISTS IN BURNING FAT AS FUEL MAINTAINS LEAN BODY TISSUE BENEFITS OF USE: 27 years of research and clinical studies at the University of Pittsburgh Medical Center have shown that groups using the nutrient pyruvate experience: 37% more weight loss, 48% more fat loss, 20% - 50% more endurance and physical performance over groups given a placebo. Pyruvate has NO SIDE EFFECTS, 100% SAFE because it is a natural product of the body's metabolism and significantly REDUCES WEIGHT REBOUND after the diet. DECREASES CHOLESTEROL in subjects on high fat diets Provides unique SUPER ANTIOXIDANT PROTECTION. May improve cardiac function. Aids in increasing muscle mass. weight loss fat loss increased endurance improved physical performance RESEARCH & STUDIES: Greenawalt, K, et al. "The effect of feeding dihydroxyacetone and pyruvate on resting energy expenditure and postprandial thermogenesis in obese women." FASEB (Federation of American Societies for Experimental Biology) JOURNAL. 1988 2(5):ABSTRACT 5371. Robertson, R.J., Stanko, R.T., Goss, F.I., Spina, R.J., Reilly, J.J., Greenawalt, K.D. "Blood glucose extraction as a mediator of percieved exertion during prolonged exercise." European Journal of Applied Physiology 61:100-105. Stanko, R T, et al. "Inhibition of regain in body weight and fat with addition of 3-carbon compounds to the diet with hyperenergetic refeeding after weight reduction." INTERNATIONAL JOURNAL OF OBESITY. 1996 20(10):925-930. DOSES & DIRECTIONS: Directions: Adults, 4-5 capsules 2 to 3 times each day on an empty stomach with water or as directed by a health care professional. or as directed by physician. KEEP OUT OF REACH OF CHILDREN INGREDIENTS: Each capsule contains Calcium Pyruvate .....500 mg** from calcium salts of Pyruvic Acid This product is derived from natural sources and is allergen free of yeast, corn, or wheat. No sugar, salt, starch, artificial coloring, flavoring, or preservatives added. **No USRDA has been established for these ingredients. 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